"models predicted the onset of Alzheimer's symptoms within a margin of three to four years…shows the feasibility of using blood tests, which are substantially cheaper and more accessible than brain imaging scans or spinal fluid tests, for predicting the onset of Alzheimer's symptoms...which will help [future patients] and their doctors develop a plan to prevent or slow symptoms...if we know how many rings a tree has, we know how many years old it is," Petersen said. "It turns out that amyloid and tau also accumulate in a consistent pattern and the age they become positive strongly predicts when someone is going to develop Alzheimer's symptoms." https://medicine.washu.edu/news/blood-test-clocks-predict-when-alzheimers-symptoms-will-start/
Predicting onset of symptomatic Alzheimerʼs disease with plasma p-tau217 clocks. 2026
[We were able to] "estimate the age at plasma %p-tau217 positivity [which] was associated with the age at onset of AD symptoms (adjusted R2 of 0.337−0.612) with a median absolute error of 3.0−3.7 years."
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