"So the pregnant person's immune system has to say, OK, sure. You know what? We're going to downregulate components of that. That's fine. But you know what? If I downregulate everything, I don't have sanitation. I don't have antibiotics. This is over most of evolutionary history. If I downregulate everything, I will die, right? And so the pregnant person's body has to do this kind of tightrope walk. It has to take those signals from the placenta to downregulate components of it. But it also needs to say - you know what? No, I can't downregulate everything. I have to upregulate some things to be able to not die of parasites and pathogens.
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