"So, the pregnant person's immune system has to... downregulate [but] has to do this kind of tightrope walk. It has to take those signals from the placenta to downregulate components of [immunity]. But it also needs to...upregulate some things to be able to not die of parasites and pathogens.
So [during evolution] the human mammal and our ancestors were starting to get a placenta. And [figuring] out how to live with each other...If the placenta is going to drag down the immune system...then the mom is going to start evolving an immune system that's actually stronger...overexpressed...so that when it's dragged down, it's [reduced] to a moderate level.
...So essentially, it's all the placenta's fault. [Females] walk around with these amped up immune systems to just survive [the placenta's] presence [hence women are predisposed to] autoimmune disorders...
No comments:
Post a Comment