Wednesday, July 30, 2014

High-dose oral acetaminophen 30 mg/kg in pediatric anesthesia

high dose (40 mg/kg) oral acetaminophen for BMT
"All 60 min plasma concentrations were ≥ 70 μmol·l–1 (ED50 for adenotonsillectomy) and less than 800 μmol·l–1 (associated with toxicity)"
http://onlinelibrary.wiley.com/doi/10.1046/j.1460-9592.2002.00743.x/abstract

acetaminophen 60 mg/kg and 90 mg/kg paracetamol in fit young adult patients undergoing third molar extractions
"90 mg/kg dose, though safe, does not offer any advantages over 60 mg/kg dose"
http://www.ncbi.nlm.nih.gov/m/pubmed/18020073/

High dose acetaminophen 40 mg/kg was better than 100 mg/kg [Wow!!]
"High dose acetaminophen (100 mg/kg) was no more effective than 40 mg/kg and was associated with increased nausea and vomiting. "
https://sciencescape.org/paper/11758634

High dose acetaminophen premed for kids having BMT.
[RCT 0,20,40 mg/kg Signif less rescue narcotic at either dosage, and 20 min longer duration and less rescue antiemetic for the high-dose group.]
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511941/

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