Wednesday, April 16, 2025

Drug-induced synaptogenesis

I knew that psilocybin induces synaptogenesis (https://journals.sagepub.com/doi/abs/10.1177/02698811241249436 ) but didn't know that ketamine did so also, let alone so rapidly. ( "By the 2-hour time point, treatment significantly increased the probability of glutamate-evoked spinogenesis to ~50%." 

0:37 a piece of mouse brain the size of a grain of sand contains 100,000 neurons and 4 km of axons extending between them and half a billion connections called synapses. 

0:55 they recorded brain activity from the mouse before its brain was mapped. (I think that's whole-brain activity and then a 3-D map of just a tiny fraction of the same brain. 

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