Saturday, August 8, 2020

Vitamin D for COVID-19: a case to answer? - The Lancet Diabetes & Endocrinology


An interesting opinion on the potential benefits of vitamin D prophylaxis to reduce the severity of COVID infection. 
There is a correlation between vitamin D deficiency and severity of COVID infection, and although there is mechanistic reasoning for a beneficial effect through immune modulation and regulation of renin-angiotensin pathway, they acknowledge this could be a spurious association. 
They assert that it would take a huge population-based study to show benefit of prophylaxis, and that administration of vitamin D as treatment after infection is confounded by the co-administration of dexamethasone. 
They conclude by saying that it's probably worth taking vitamin D at least for its bone and muscle effects, even if this association with reduced COVID severity proves to be spurious. 

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