Tuesday, September 30, 2025

Brandon Stanton, the man behind "Humans of New York."

https://youtu.be/hWcbR9St1ig?si=lU5xD7Ir9pXu9aAR

9:30 "If you can find someone's struggle, you can find their genius, because you find the things they've pushed up against, they've thought about, that's kept them awake at night... When you find that...you find the things that they can tell the world that is different than everybody else." 

What will super intelligence do to my children's future?

https://youtu.be/5KmopXwjXik?si=T3maxHJbnspzq_c1

At 10:22 this insightful thinker Geoffrey Hinton elaborates on what the future of AI could mean for human usefulness in the future. 
14:56 AI will increase income inequality. 
16:28 a lengthy argument that AI has achieved immortality. 
17:57 human conversation at its best can transfer 10 bits of information a second, but it's sending it to another person's brain that functions very differently with unique connections and life experiences. But an AI can transfer trillions of bits per second to another AI clone that is functioning exactly the same way on the same background of learning and experience. 
20:30 people believe humans are uniquely creative, but part of creativity is about seeing unusual analogies, and AI will develop understanding of many more analogies than one human can, and will be much more creative. 

[As an early example, see this AI art 

Monday, September 29, 2025

Sunday, September 28, 2025

Three Gorges dam slowed the earth's spinning

Picture a figure skater spinning with arms stretched out. When the skater pulls in their arms, the spin speeds up; when they extend their arms, they slow down. Similarly, Earth's spin slows by a tiny amount when more mass moves away from its axis. The reservoir is like the skater's arms stretched out, causing a subtle slowdown of about 0.06 microseconds in the length of each day.

Is that milk in the fridge still ok to drink?

Milk is ok to drink for longer than the frequent recommendation of 7 days after it's opened. Bacteria did not start to proliferate until 13 days after opening during proper (4-degree Celsius) storage. "The total bacterial count in pasteurized milk exhibited accelerated microbial growth from day 13 onwards." This study used PCR methods, much like COVID testing, to look for DNA rates than just trying to grow bacteria in a petri dish. That's important because 99.999% of bacteria are unknown - we know if about 43000 species out of the estimated trillions of bacterial species. 

What about the expiration date? Milk can still be ok, even for several days after its expiration date, for several days after opening. Once it's 6 days after expiry, it goes bad within 48 hours after opening - see graph. 

Surprisingly, we can safely drink milk with 100,000 bacteria* per ml, or 500,000 in a teaspoon. Above that, it drops to "grade B" milk up until 300,000 bacteria per ml.  Safe numbers of coliform bacteria (from poop) are much much lower at 10 per ml.

Not surprising, I guess, when you see the conditions in even the most well-maintained dairy farms. Of course, the cows' teats are very thoroughly sanitized  before milking, and even occasionally singed with an open flame to remove hairs that might harbor bacteria. 

Also, be sure to store your milk in a part of the fridge that stays cold when you open it, not in the door of the fridge. 

*technically, it's "colony-forming units" rather than bacteria, since you can't tell if a spot of growth on a petri dish came from just one bacterium or a clump of many. 

Friday, September 26, 2025

Epic Bird battle

Who's gonna win? What an epic prolonged struggle between these birds. 
So many questions. At an evolutionary level, I'm surprised it's worth fighting this hard to steal food rather than the gull just going and getting his own food. Why do the other terns fight so hard for a piece of food they know they won't get if they win - is that just preservation of their species? How is the one tern smart enough to know that by grabbing the other tern's break it tightens their hold to prevent it getting snatched? 


Commentary on studio singing technique Izzy Escobar

https://youtube.com/shorts/porirWx9MyE?si=cAEc05xKfxCKwzmr

Wednesday, September 24, 2025

How "Open Evidence" makes money

Until a warning today (from our CEO of medical informatics) explaining why he blocked access to Open Evidence, I hadn't thought about how this platform plans to make (big) money, and the risks associated with sharing questions with them (if it ever could be traced back to the individual patient.) He argues there could be inadvertent recording of, or sharing of personal health information etc. 

Open Evidence is an AI platform that uses only peer-reviewed reviewed articles in its large-language model (LLM) providing a synthesis of recent requirement information to boost clinicians. The following "business case analysis" is probably exaggerated and overly optimistic, but the numbers are staggering. 

Open Evidence Business case: monetization strategy analysis. Trey Rawles April 2025

$1 billion valuation...strategic partnerships, particularly with the New England Journal of Medicine...440,000+ verified doctor users across the United States...40,000 new verified healthcare providers registering monthly...75%+ of users utilize the platform during office hours for clinical decision support...Global healthcare AI market size: Estimated at $11 billion in 2023...Team largely composed of AI scientists from Harvard and MIT with healthcare expertise...OpenEvidence focuses solely on augmenting clinical decision-making...Target: 1,000+ major health systems in the US...Average annual enterprise license: $500,000-$2,000,000...Similar enterprise models have proven successful for companies like Palantir, Snowflake, and Databricks, which offer free tiers but generate significant revenue through enterprise contracts...OpenEvidence Pro: Subscription tier ($99-299/month) for individual practitioners...
Premium Features Could Include:
Priority computation resources for faster response times

Advanced visualization tools for complex cases

Custom knowledge base creation and curation

Specialized modules for different medical specialties

Enhanced patient education materials generation

Personalized practice pattern insights and analytics

CME (Continuing Medical Education) credit integration

Expanded citation functionality and research tools

Revenue Potential:
Target conversion rate: 15-25% of free users

Potential subscribers at current user base: 66,000-110,000

Annual revenue at $1,200-3,000 per subscriber: $79-330 million

The aggregated, anonymized knowledge generated from millions of clinical queries represents invaluable insights for various stakeholders...Trend Analysis: Selling aggregate, anonymized insights on treatment patterns, diagnostic questions, and emerging clinical concerns...Pharmaceutical companies,Medical device manufacturers,Healthcare policymakers,Research institutions,Medical education providers,Health insurers,Public health agencies...Data insights subscriptions: $100,000-$1,000,000+ annually per client

Phase 1: Foundation Building (2023-2025)
Phase 2: Monetization Expansion (2026-2027)
Phase 3: Global Scaling (2028-2030)


Sunday, September 21, 2025

Plastic recycling may be harmful

https://youtu.be/D1rJNSVnpfI?si=2Y2qvlYHhMOXrs0v

As she admits at the end, she may have an unpopular opinion. But encouragement to recycle may be playing mind games with us, only to encourage us to consume more plastic. A well-managed landfill may be better, overall, for the environment. 

Shrinking hotel rooms

https://youtu.be/116cwKs2XQs?si=RU-5kC0Wlj7krPef

How hotels have shrunk room size but still kept guest ratings high. 

Monday, September 15, 2025

Medicare explained

If you're in the US and, like me, approaching age 65, it's essential to understand Medicare. This is the best explanation of Medicare parts A,B,& D and when and why to sign up for them. Essential reading.

Saturday, September 13, 2025

Eyestalk ablation to accelerate spawning in shrimp

"Eyestalk ablation is commonly practiced in crustacean to induce ovarian maturation in captivity." 

"analysis revealed that the activation of gonadotropin-releasing hormone signaling, calcium signaling, and progesterone-mediated oocyte maturation pathways were putatively crucial to ovarian maturation induced by the ablation. These findings shed light on several possible molecular mechanisms of the eyestalk ablation effect and allow more focused investigation for an ultimate goal of finding alternative methods to replace the undesirable practice of the eyestalk ablation in the future." https://pmc.ncbi.nlm.nih.gov/articles/PMC3168472/ 

Sunday, September 7, 2025

How to get back to sleep



https://youtu.be/LNAOgq2UqSk?si=oVyY4ly3JvFHIUkY

1:58 eyes closed pattern of moving your eyes: up, down, then clockwise then CCW then cross-eyed. Forces a vagal reaction that helps induce sleep... 

How to walk uphill

How to walk uphill - this makes a lot of sense to me. 1:40 Plant your heels under your shoulders and take small steps. 

Then when walking downhill 5:24 walk with your legs bent to absorb the shock. 

Saturday, September 6, 2025

This is so corrupt!

https://youtu.be/BsrAZ0gnkPo?si=wUTo-lbxKEQL5jpE

When you have 10 minutes, take a look at this video describing in detail how our representatives in Congress are making huge profits from inside information gained from committees they serve on. They give so many examples in this video. 

The only good news is that "Quiver Quantitative" tracks investments made by members of Congress to select stock trades, which are doing 50% better than the market. They publish their list of Congress members' trades here, and you can copy their trading strategy on Quantbase in a totally automated account. 

Friday, September 5, 2025

Toothbrushing on your non-dominant side

I think that right-handed people have less plaque on the left side (presumably because the ergonomics are easier on the opposite of their dominant hand)? Study: "RH subjects had higher average of plaque index in upper left quadrants compared to upper right quadrants (P=0.044)"

Search This Blog

Followers