high dose (40 mg/kg) oral acetaminophen for BMT
"All 60 min plasma concentrations were ≥ 70 μmol·l–1 (ED50 for adenotonsillectomy) and less than 800 μmol·l–1 (associated with toxicity)"
http://onlinelibrary.wiley.com/doi/10.1046/j.1460-9592.2002.00743.x/abstract
acetaminophen 60 mg/kg and 90 mg/kg paracetamol in fit young adult patients undergoing third molar extractions
"90 mg/kg dose, though safe, does not offer any advantages over 60 mg/kg dose"
http://www.ncbi.nlm.nih.gov/m/pubmed/18020073/
High dose acetaminophen 40 mg/kg was better than 100 mg/kg [Wow!!]
"High dose acetaminophen (100 mg/kg) was no more effective than 40 mg/kg and was associated with increased nausea and vomiting. "
https://sciencescape.org/paper/11758634
High dose acetaminophen premed for kids having BMT.
[RCT 0,20,40 mg/kg Signif less rescue narcotic at either dosage, and 20 min longer duration and less rescue antiemetic for the high-dose group.]
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511941/
Wednesday, July 30, 2014
Fwd: Better mental state with spinal anesthesia with no sedation
General or spinal anesthesia: which is better in the elderly?
Chung F, et al. Anesthesiology. 1987.
http://www.ncbi.nlm.nih.gov/m/pubmed/3307537/
Anaesthesia for hip fracture surgery in adults.
Cochrane Database Syst Rev. 2016
...comparison of regional versus general anaesthesia for hip (proximal femoral) fracture repair in adults...We did not find a difference between the two techniques, except for deep venous thrombosis in the absence of potent thromboprophylaxis... large randomized trials reflecting actual clinical practice are required before drawing final conclusions. PMID 26899415
Anaesthesia for hip fracture surgery in adults.
Cochrane Database Syst Rev. 2016
...comparison of regional versus general anaesthesia for hip (proximal femoral) fracture repair in adults...We did not find a difference between the two techniques, except for deep venous thrombosis in the absence of potent thromboprophylaxis... large randomized trials reflecting actual clinical practice are required before drawing final conclusions. PMID 26899415
Confirmed in one study:
Not confirmed in other studiesBetter mental state with spinal anesthesia with no sedation
https://link.springer.com/content/pdf/10.1007/BF03005334.pdf
"A significant intragroup difference between preoperative and postoperative MMS score was detected in the GA group"
"A significant intragroup difference between preoperative and postoperative MMS score was detected in the GA group"
Wednesday, July 23, 2014
Evaluating informed consent obtained by surgical residents.
Not the result I was expecting when I looked up this study.
"Ninety-nine per cent of patients reported that the resident adequately described the procedure and nine per cent had additional questions for the attending physician. Major surgery-specific complications were discussed with 89 per cent of patients. Benefits of the procedure were discussed with 96 per cent and alternatives with 85 per cent of patients. Residents received an overall grade of excellent (74% of patients), good (25%), or fair (1%)."
http://www.ncbi.nlm.nih.gov/m/pubmed/24887738/
"Ninety-nine per cent of patients reported that the resident adequately described the procedure and nine per cent had additional questions for the attending physician. Major surgery-specific complications were discussed with 89 per cent of patients. Benefits of the procedure were discussed with 96 per cent and alternatives with 85 per cent of patients. Residents received an overall grade of excellent (74% of patients), good (25%), or fair (1%)."
http://www.ncbi.nlm.nih.gov/m/pubmed/24887738/
| Hope WW, Walters K, Bools LM, Adams A, Hooks WB 3rd, Clancy TV. | Related Articles | |
| Evaluating informed consent obtained by surgical residents. | ||
| Am Surg. 2014 May;80(5):522-4. | ||
| PMID: 24887738 | ||
Sunday, July 20, 2014
Cool trailers
Cricket, Alto Safari, UEV440, Diubleback
http://youtu.be/eqhsfrM96SQ
http://youtu.be/OssiS9Rpo98
http://youtu.be/XxvfDTaUVAo
http://youtu.be/GIG9P0lB1iA
http://youtu.be/eqhsfrM96SQ
http://youtu.be/OssiS9Rpo98
http://youtu.be/XxvfDTaUVAo
http://youtu.be/GIG9P0lB1iA
Saturday, July 5, 2014
How text-to-speech is made
To say the word "impressive" the voice engine stitches together parts of the words "important," "president," and "detective" from recordings of a boy reading words.
Monday, June 16, 2014
Persian rug photo
This self-taught Iranian photographer places Persian rugs in unusual places.
http://ajammc.com/2012/12/22/persian-rugs-the-iranian-everyday-jalal-sepehr-in-yazd/My favorite is this one:
Warning of the fallacy of p values
" the surprisingly slippery nature of the P value, which is neither as reliable nor as objective as most scientists assume."
"...suggested that most published findings are false"
"a P value of 0.05 became enshrined as 'statistically significant', for example. "The P value was never meant to be used the way it's used today,""
"Most scientists would look at his original P value of 0.01 and say that there was just a 1% chance of his result being a false alarm. But they would be wrong. The Pvalue cannot say this: all it can do is summarize the data assuming a specific null hypothesis. It cannot work backwards and make statements about the underlying reality. That requires another piece of information: the odds that a real effect was there in the first place. To ignore this would be like waking up with a headache and concluding that you have a rare brain tumour "
Wednesday, June 11, 2014
Okanagan wines:
"So... that's a tough question. Meritage from BC is usually a good place to start. There are some great ones.
My bias is that Nk'mip is good, but well marketed and a bit overpried. Their Meritage can be nice but as you said $63/bottle and I think there are other wines of equal quality for lower price.
Osoyoos Larose used to be $60 but is now $45. Its a cult wine, well marketed again, but has a big following. Marek, Ian and myself in various combinations have done blind tests and enjoyed it, but... The Petales d'Osoyoos is their second label. Usually around $25 I think, and not much different (you aren't paying for the label then).
Cerelia and Fort Berens both have really good Meritages if you can find them (Discovery or the wine museum would be your best bets). Fort Berens is from Lillooett but sources much of their Meritage grape from the Osoyoos region, Cerelia is a small estate winery from Keremeos.
Also from Keremeos is Orofino. Their Passion Pit Cab Sauv has been really tasty if you can find it (you can order it from them) and they make a Beleza blend (both $25-$38).
La Frenz on the Naramata Bench is great. Their Montage ($22) has gone really well with steak, but their Grand Total is that much better ($40/bottle) depending on how you are feeling.
Burrowing Owl (down near Oliver) of course is a generally good winery and if you can find their Meritage its worth trying a few bottles. We've also enjoyed the Athene and Cab Franc. (I think they are all in the $30 range).
If you want to spend more and can find it Hester Creek's "The Judge" is great, but needs to be aged. Le Vieux Pin's Syrah is really nice, their Equinoxe wines are big and need to be aged but tastes great!
Another caveat. Most of the wineries are selling their 2011 reds right now. I'm not a fan of these wines. I think the Okanagan gives nice rounded fruit characteristics and this was a more acidic year without the earthiness and tannin that can balance it. Depends upon the winery and such but often I've been dissapointed. 2010 and 2009 seem to have been better. 2012 may be a bit off, 2013 looks like it should be good.
Is that a good start?"
My bias is that Nk'mip is good, but well marketed and a bit overpried. Their Meritage can be nice but as you said $63/bottle and I think there are other wines of equal quality for lower price.
Osoyoos Larose used to be $60 but is now $45. Its a cult wine, well marketed again, but has a big following. Marek, Ian and myself in various combinations have done blind tests and enjoyed it, but... The Petales d'Osoyoos is their second label. Usually around $25 I think, and not much different (you aren't paying for the label then).
Cerelia and Fort Berens both have really good Meritages if you can find them (Discovery or the wine museum would be your best bets). Fort Berens is from Lillooett but sources much of their Meritage grape from the Osoyoos region, Cerelia is a small estate winery from Keremeos.
Also from Keremeos is Orofino. Their Passion Pit Cab Sauv has been really tasty if you can find it (you can order it from them) and they make a Beleza blend (both $25-$38).
La Frenz on the Naramata Bench is great. Their Montage ($22) has gone really well with steak, but their Grand Total is that much better ($40/bottle) depending on how you are feeling.
Burrowing Owl (down near Oliver) of course is a generally good winery and if you can find their Meritage its worth trying a few bottles. We've also enjoyed the Athene and Cab Franc. (I think they are all in the $30 range).
If you want to spend more and can find it Hester Creek's "The Judge" is great, but needs to be aged. Le Vieux Pin's Syrah is really nice, their Equinoxe wines are big and need to be aged but tastes great!
Another caveat. Most of the wineries are selling their 2011 reds right now. I'm not a fan of these wines. I think the Okanagan gives nice rounded fruit characteristics and this was a more acidic year without the earthiness and tannin that can balance it. Depends upon the winery and such but often I've been dissapointed. 2010 and 2009 seem to have been better. 2012 may be a bit off, 2013 looks like it should be good.
Is that a good start?"
Monday, June 9, 2014
The best message is no message.
Interesting psychology here. As I see it, discovering by yourself that something is yummy is more powerful than having someone else tell you it's good.
http://nyti.ms/1kNQQls
To persuade children to eat healthy food, new research suggests that giving no message at all trumps any other persuasion.
http://nyti.ms/1kNQQls
To persuade children to eat healthy food, new research suggests that giving no message at all trumps any other persuasion.
Tuesday, June 3, 2014
Sign of the times.
My wife got a handwritten letter from our college-age daughter, and didn't recognize her writing at all.
Wistful quotation
"there was a calmness and simplicity to life that seems achingly
appealing by the frantic standards of our sleek, cyber-driven times"
appealing by the frantic standards of our sleek, cyber-driven times"
-Ring Lardner
Saturday, May 31, 2014
Thursday, May 29, 2014
$500 pizza tips carry legacy of brother's last wish
Heartwarming story. Hope you like it.
http://www.cbc.ca/newsblogs/yourcommunity/2013/07/500-tips-leave-legacy-after-brothers-death.html
http://www.cbc.ca/newsblogs/yourcommunity/2013/07/500-tips-leave-legacy-after-brothers-death.html
Sunday, May 25, 2014
Great jobs to do in retirement
Deliver new RVs to dealers/buyers, or transport and drive a combine, flowing the harvest northward across the continent.
30% of their drivers are seniors
http://www.rvtransport.com/
30% of their drivers are seniors
http://www.rvtransport.com/
"Is harvest your favourite time of year? Can't get enough running combine? Have a passion for farming? Love to see the open road through the windshield of a semi? Enjoy a job well done? Want to see the most advanced farming operations of North America? Love to travel? If you answered yes to all of the above then we may have the job for you!"
Subscribe to:
Posts (Atom)